*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DI8530000
CHEMICAL NAME           : Benzo(c)phenanthrene-3-alpha,4-beta-diol,
                          1,2,3,4-tetrahydro-1-beta,2-beta-epoxy-, (+-)-
CAS REGISTRY NUMBER     : 75410-89-8
LAST UPDATED            : 199410
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H14-O3
MOLECULAR WEIGHT        : 278.32
WISWESSER LINE NOTATION : T D3 C6 B666 EOTT&&&J GQ HQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * B(c)PH diol epoxide-1
   * (+-)-Benzo(c)phenanthrene-3,4-diol-1,2-epoxide-1
   * syn-Benzo(c)phenanthrene-3,4-diol-1,3-oxide
   * Benzo(5,6)phenanthro(3,4-b)oxirene-2,3-diol, 1a,2,3,11d-tetrahydro-,  
   (+-)-
   *   (+-)-3-alpha,4-beta-Dihydroxy-1-beta,2-beta-epoxy-1,2,3,4-tetrahydrobenz
     o(c)phenanthrene
   * r-4,t-3-Dihydroxy-t-1,2-oxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 278 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,2257,1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 pmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   51,1659,1991
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 pmol/tube
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   51,1659,1991
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 144 nmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   80,177,1991
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 200 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,2876,1980
 
                            *** END OF RECORD ***