*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DI9870000
CHEMICAL NAME           : Benzo(b)(1,10)phenanthroline,
                          7-(3-(N-(2-chloroethyl)-N-propylamino)propylamino)-,
                          trihydrochloride
CAS REGISTRY NUMBER     : 38915-59-2
LAST UPDATED            : 199410
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H27-Cl-N4.3Cl-H
MOLECULAR WEIGHT        : 516.38
WISWESSER LINE NOTATION : T D6 B666 CN RNJ JM3N3&2G &GH 3
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   *   7-(3-(2-Chloroethyl-n-propylamino)propylamino)benzo(b)(1,10)-phenathroli
     ne hydrochloride
   * ICR 394
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1136 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1550 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2423,1976
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                            *** END OF RECORD ***