*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DJ2850000 CHEMICAL NAME : (2)Benzopyrano(3,4-g)indole, 1,2,3,5a,7,11b,11c-octahydro-9,10-dimethoxy-7-ethoxy- 1-methyl-, hydrochloride CAS REGISTRY NUMBER : 75917-42-9 LAST UPDATED : 199512 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C20-H27-N-O4.Cl-H MOLECULAR WEIGHT : 381.94 WISWESSER LINE NOTATION : T C5 B666 DN KO GU NU PUTJ D1 LO2 OO1 PO1 &GH COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 9,10-Dimethoxy-7-ethoxy-1-methyl-1,2,3,5a,7,11b,11c-octahydro(2)benzopyr ano(3,4-g)indole HCl * 9-O-Ethyl lycorenine hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 765 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 1,30,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 106 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 1,30,1980 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >60 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Gastrointestinal - changes in structure or function of salivary glands Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 1,30,1980 *** END OF RECORD ***