*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ2900000
CHEMICAL NAME           : 2H-1-Benzopyran-6-ol,
                          3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltr
                          idecyl)-, (2R-(2R*(4R*,8R*)))-
CAS REGISTRY NUMBER     : 59-02-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C29-H50-O2
MOLECULAR WEIGHT        : 430.79
WISWESSER LINE NOTATION : T66 BOT&J C3Y1&3Y1&3Y1&1 C1 G1 HQ I1 J1
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Almefrol
   * Antisterility vitamin
   * Covi-Ox
   * Covitol F 1000
   * Denamone
   * Emipherol
   * Endo E
   * Eprolin
   * Epsilan
   * Esorb
   * Etamican
   * Etavit
   * Evion
   * Evitaminum
   * Ilitia
   * Phytogermine
   * Profecundin
   * Spavit E
   * Syntopherol
   * d-alpha-Tocopherol
   * (R,R,R)-alpha-Tocopherol
   * alpha-Tocopherol
   * (2R,4'R,8'R)-alpha-Tocopherol
   * Tokopharm
   * 5,7,8-Trimethyltocol
   * Vascuals
   * Verrol
   * Vitamin E alpha
   * Vitaplex E
   * Vitayonon
   * Viteolin
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 mg/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   69,293,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 27 nmol/kg
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 31,1023,1975
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,337,1985

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5582
       No. of Facilities: 279 (estimated)
       No. of Industries: 4
       No. of Occupations: 8
       No. of Employees: 6957 (estimated)
       No. of Female Employees: 3599 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***