*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ5010000
CHEMICAL NAME           : Benzo(a)pyrene, 9,10-dihydro-9,10-dihydroxy-
CAS REGISTRY NUMBER     : 24909-09-9
LAST UPDATED            : 199410
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H14-O2
MOLECULAR WEIGHT        : 286.34
WISWESSER LINE NOTATION : L D6 B6666 2AB T GUT&&&&J EQ FQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 9,10-Dihydrobenzo(a)pyrene-9,10-diol
   * 9,10-Dihydro-9,10-dihydroxybenzo(a)pyrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   34,523,1976
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4580 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CCSUDL Carcinogenesis--A Comprehensive Survey.  (Raven Press, 1185 Ave. of
   the Americas, New York, NY 10036)  V.1-    1976-  Volume(issue)/page/year:
   3,371,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4580 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1981,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 30 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   41,155,1982
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2059,1976

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse prostate

 
                            *** END OF RECORD ***