*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ6315400
CHEMICAL NAME           : Benzo(a)pyrene-3,6-dione
CAS REGISTRY NUMBER     : 3067-14-9
BEILSTEIN REFERENCE NO. : 2334218
REFERENCE               : 3-07-00-04370 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C20-H10-O2
MOLECULAR WEIGHT        : 282.30
WISWESSER LINE NOTATION : L D6 B6666 2AB T JV OVJ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 3,6-Benzo(a)pyrenedione
   * Benzo(a)pyrene-3,6-quinone
   * BP-3,6-Quinone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4520 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CCSUDL Carcinogenesis--A Comprehensive Survey.  (Raven Press, 1185 Ave. of
   the Americas, New York, NY 10036)  V.1-    1976-  Volume(issue)/page/year:
   3,371,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,839,1985
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 umol/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 28,37,1985
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,3350,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 161,173,1986

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***