*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ6380000
CHEMICAL NAME           : Benzo(a)pyrene, 9,10-epoxy-7,8,9,10-tetrahydro-
CAS REGISTRY NUMBER     : 36504-68-4
BEILSTEIN REFERENCE NO. : 4192582
REFERENCE               : 5-17-02-00509 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C20-H14-O
MOLECULAR WEIGHT        : 270.34
WISWESSER LINE NOTATION : T E3 D6 B6666 2AB U FOTT&&&&J
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Benzo(a)pyrene-9,10-epoxide, 7,8,9,10-tetrahydro-
   * Benzo(a)pyrene-9,10-epoxyide, 7,8,9,10-tetrahydro-
   * Benzo(a)pyrene, 7,8,9,10-tetrahydro-9,10-epoxy-
   * 9,10-Epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 519 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,3356,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 pmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,642,1980
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 300 pmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,3358,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 ug/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 74,1378,1977
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 60 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,3358,1976
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,247,1982

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ABSYB2 Alfred Benzon Symposium.  (Nankodo Co. Ltd., POB 5272, Tokyo
   International 100-31, Japan) V.1-    1968-  Volume(issue)/page/year:
   10,261,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Negative: Cell transform.-mouse prostate
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat

 
                            *** END OF RECORD ***