*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AG0440000
CHEMICAL NAME           : Acetic acid, (p-chlorophenoxy)-, 2-dimethylaminoethyl
                          ester, hydrochloride
CAS REGISTRY NUMBER     : 3685-84-5
LAST UPDATED            : 199603
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C12-H16-Cl-N-O3.Cl-H
MOLECULAR WEIGHT        : 294.20
WISWESSER LINE NOTATION : GR DO1VO2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acefen
   * Acephen
   * Acetic acid, (4-chlorophenoxy)-, 2-(dimethylamino)ethyl ester,  
   hydrochloride
   * Amipolen
   * 235 Anp hydrochloride
   * Atsefen
   * Brenal
   * Cellative
   * Centrofenoxin
   * Centrophenoxine
   * Centrophenoxine hydrochloride
   * Cerutil
   * (p-Chlorophenoxy)acetic acid 2-(dimethylamino)ethyl ester hydrochloride
   * Chlorowodorki centrofenoksyna
   * p-Chlorphenoxyessigsaeure-beta-dimethylaminoaethylesters
   * Dimethylaminoethyl p-chlorophenoxyacetate hydrochloride
   * Dimethylaminoethyl 4-chlorophenoxyacetate hydrochloride
   * Dimethylaminoethyl ester of p-chlorophenoxyacetic acid hydrochloride
   * Helfergin
   * Lucidril
   * Lucidryl hydrochloride
   * Marucotol
   * Meclofenoxate hydrochloride
   * Meclophenoxate hydrochloride
   * Methoxynal
   * MKO
   * NSC 113619
   * Proserout
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 865 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSKZAN Khimiya v Sel'skom Khozyaistve.  Chemistry in Agriculture.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  No.1-    1963-
   Volume(issue)/page/year: 16(2),59,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 153,1914,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,814,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1560 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,814,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #398M
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 153,1914,1959
 
                            *** END OF RECORD ***