*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AG3150000
CHEMICAL NAME           : Acetic acid, cobalt(2+) salt
CAS REGISTRY NUMBER     : 71-48-7
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C4-H6-O4.Co
MOLECULAR WEIGHT        : 177.03
WISWESSER LINE NOTATION : OV1 2 &-CO-
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Bis(acetato)cobalt
   * Cobalt acetate
   * Cobalt(2+) acetate
   * Cobalt acetate (Co(OAc)2)
   * Cobalt(II) acetate
   * Cobalt diacetate
   * Cobaltous acetate
   * Cobaltous diacetate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 503 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   20,311,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 23,455,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 23,455,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/m3/24H/17W-C
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(11-12),22,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg/9D-I
TOXIC EFFECTS :
   Cardiac - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
   Biochemical - Neurotransmitters or modulators (putative) - catecholamine
   levels in sympathetic nerves
REFERENCE :
   KARDA2 Kardiologiia.  (Izdatel'stvo Meditsina, Petroverigskii pereulok 6/8
   101000 Moscow, Russia) V.1-    1989-  Volume(issue)/page/year: 18,54,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 200 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,193,1979

                              *** REVIEWS ***
 
   IARC Cancer Review:Human Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 52,363,1991

   IARC Cancer Review:Group 2B
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 52,363,1991

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81777
       No. of Facilities: 603 (estimated)
       No. of Industries: 8
       No. of Occupations: 20
       No. of Employees: 5023 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81777
       No. of Facilities: 622 (estimated)
       No. of Industries: 13
       No. of Occupations: 16
       No. of Employees: 15156 (estimated)
       No. of Female Employees: 4580 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***