*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AG3480000
CHEMICAL NAME : Acetic acid, copper(2+) salt
CAS REGISTRY NUMBER : 142-71-2
LAST UPDATED : 199701
DATA ITEMS CITED : 41
MOLECULAR FORMULA : C4-H6-O4.Cu
MOLECULAR WEIGHT : 181.64
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acetate de cuivre
* Acetic acid, cupric salt
* Copper(2+) acetate
* Copper(II) acetate
* Copper acetate (cu(C2H3O2)2)
* Copper diacetate
* Copper(2+) diacetate
* Crystallized verdigris
* Crystals of venus
* Cupric acetate
* Cupric diacetate
* Neutral verdigris
* Octan mednaty
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 501 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14700 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 350 mg/kg
TOXIC EFFECTS :
Musculoskeletal - joints
Tumorigenic - active as anti-cancer agent
Biochemical - Metabolism (Intermediary) - effect on inflammation or
mediation of inflammation
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52
Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year:
15,211,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17100 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 196 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
30,771,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
Volume(issue)/page/year: 23,153,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 56 mg/kg/7D-I
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 33,92,1984
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 40 mg/kg
SEX/DURATION : female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 166,1237,1972
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-AUSTRALIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-AUSTRALIA:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-BELGIUM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-BELGIUM:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-DENMARK:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-DENMARK:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-FINLAND:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-FINLAND:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-FRANCE:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-FRANCE:TWA 1 mg(Cu)/m3;STEL 2 mg(Cu)/m3 (dust) JAN 1993
OEL-GERMANY:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-GERMANY:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-HUNGARY:TWA 0.2 mg(Cu)/m3;STEL 0.4 mg(Cu)/m3 (dust) JAN 1993
OEL-INDIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 02 mg(Cu)/m3 (fume) JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Cu)/m3 (dust) JAN 1993
OEL-THE PHILIPPINES:TWA 1.0 mg(Cu)/m3 (fume) JAN 1993
OEL-POLAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-RUSSIA:STEL 0.5 ppm (1 mg(Cu)/m3) (dust) JAN 1993
OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (resp. dust) JAN 1993
OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-SWEDEN:TWA 1 mg(Cu)/m3 (total dust) JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(Cu)/m3;STEL 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-SWITZERLAND:TWA 1 mg(Cu)/m3;STEL 1 mg(Cu)/m3 JAN 1993
OEL-THAILAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993
OEL-THAILAND:TWA 1 mg(Cu)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg(Cu)/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84332
No. of Facilities: 139 (estimated)
No. of Industries: 4
No. of Occupations: 5
No. of Employees: 565 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84332
No. of Facilities: 550 (estimated)
No. of Industries: 10
No. of Occupations: 13
No. of Employees: 15459 (estimated)
No. of Female Employees: 10534 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***