*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AG9625000
CHEMICAL NAME           : Acetic acid,
                          (4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-,
                          propyl ester
CAS REGISTRY NUMBER     : 1421-14-3
BEILSTEIN REFERENCE NO. : 2952046
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C18-H27-N-O5
MOLECULAR WEIGHT        : 337.46
WISWESSER LINE NOTATION : 3OV1R CO1 DO1VN2&2
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Acetic acid, (p-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-, propyl  
   ester
   * B1420
   * BAY 1420
   * Bayer 1420
   * Benzeneacetic acid, 4-(2-(diethylamino)-2-oxoethoxy)-3-methoxy-, propyl  
   ester
   * 4-(2-(Diethylamino)-2-oxoethoxy)-3-methoxybenzeneacetic acid propyl ester
   * (p-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid propyl ester
   * (4-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid propyl ester
   * Eponthol
   * Epontol
   * Fabantol
   * Fabontal
   * FBA 1420
   * (3-Methoxy-4-((N,N-diethylcarbamido)methoxy)phenyl)acetic acid n-propyl  
   ester
   * Propanidid
   * Propanidide
   * Propantan
   * Propyl(4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetate
   * 13245 R. P.
   * Sombrevin
   * 2180 TH
   * WH 5668
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Biochemical - Metabolism (Intermediary) - histamines (including liberation
   not immunochemical in origin)
REFERENCE :
   BJANAD British Journal of Anesthesia.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1923-  Volume(issue)/page/year:
   45,1097,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 81 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AASXAP Acta Anaesthesiologica Scandinavica, Supplementum.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1959- 
   Volume(issue)/page/year: 17,21,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 19,845,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AASXAP Acta Anaesthesiologica Scandinavica, Supplementum.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1959- 
   Volume(issue)/page/year: 17,21,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AASXAP Acta Anaesthesiologica Scandinavica, Supplementum.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1959- 
   Volume(issue)/page/year: 17,21,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AASXAP Acta Anaesthesiologica Scandinavica, Supplementum.  (Munksgaard
   International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1959- 
   Volume(issue)/page/year: 17,21,1965
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 1-60 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Effects on Newborn - physical
REFERENCE :
   NYSJAM New York State Journal of Medicine.  (Medical Soc. of the State of
   New York, POB 5405, Lake Success, NY 11042)  V.1-    1901-
   Volume(issue)/page/year: 64,2177,1964
 
                            *** END OF RECORD ***