*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AF5775000
CHEMICAL NAME           : Acetic acid,
                          bis(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-, ethyl
                          ester
CAS REGISTRY NUMBER     : 548-00-5
LAST UPDATED            : 199609
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C22-H16-O8
MOLECULAR WEIGHT        : 408.38
WISWESSER LINE NOTATION : T66 BOVJ EQ DYVO2&- DT66 BOVJ EQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Bis(4-hydroxy-3-coumarin)acetic acid ethyl ester
   * Bis-(4-hydroxy-3-coumarinyl)ethyl acetate
   * Bis-3,3'-(4-hydroxycumarinyl)acetic acid ethyl ester
   * Bis(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)acetic acid ethyl ester
   * BOEA
   * 3,3'-Carbaethoxymethylen-bis-(4-oxy-cumarin)
   * 3,3'-(Carboxymethylene)bis(4-hydroxycoumarin) ethyl ester
   * Dicumacyl
   * Ethyl biscoumacetate
   * Ethyl bis(4-hydroxycoumarinyl)acetate
   * Ethyl bis(4-hydroxy-3-coumarinyl)acetate
   * Ethyldicoumarol acetate
   * Ethyl 4,4'-dihydroxydicoumarinyl-3,3'-acetate
   * Neodicoumarin
   * Neodicoumarol
   * Neodicumarinum
   * Neodicumarol
   * Neodikumarin
   * Pelentan
   * Trombarin
   * Trombil
   * Trombolysan
   * Tromexan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 10,303,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Cardiac - change in force of contraction
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 87,402,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 222,107,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 10,303,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,611,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 222,107,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 10,303,1951
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 48 mg/kg
SEX/DURATION            : female 36-37 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,719,1955
 
                            *** END OF RECORD ***