*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DL0280000
CHEMICAL NAME           : 1,5-Benzothiazepin-4(5H)-one,
                          3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-
                          2-(4- methoxyphenyl)-, (2S-cis)-
CAS REGISTRY NUMBER     : 42399-41-7
BEILSTEIN REFERENCE NO. : 3573079
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H26-N2-O4-S
MOLECULAR WEIGHT        : 414.56
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Diltiazem
   * (+)-Diltiazem
   * (+)-cis-Diltiazem
   * d-cis-Diltiazem
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 740 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
   2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan)  V.1-   1988-
   Volume(issue)/page/year: 4,121,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
   2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan)  V.1-   1988-
   Volume(issue)/page/year: 4,121,1991
 
                            *** END OF RECORD ***