*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DL0858800
CHEMICAL NAME           : 2-Benzothiazolamine,
                          N-(1-(4-(4-fluorophenoxy)butyl)-4-piperidinyl)-N-meth
                          yl-
CAS REGISTRY NUMBER     : 104606-13-5
BEILSTEIN REFERENCE NO. : 6616961
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C23-H28-F-N3-O-S
MOLECULAR WEIGHT        : 413.60
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   N-(1-(4-(4-Fluorophenoxy)butyl)-4-piperidinyl)-N-methyl-2-benzothiazolam
     ine
   * R 56865
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 154 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,238,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,238,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13600 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,238,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 14100 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,238,1990
 
                            *** END OF RECORD ***