*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DM3675000
CHEMICAL NAME           : 4H-1,3-Benzoxazin-4-one,
                          2-(2-chloroethyl)-2,3-dihydro-
CAS REGISTRY NUMBER     : 132-89-8
BEILSTEIN REFERENCE NO. : 0170863
REFERENCE               : 4-27-00-02766 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H10-Cl-N-O2
MOLECULAR WEIGHT        : 211.66
WISWESSER LINE NOTATION : T66 BVM EO DHJ D2G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AP 67
   * Apirazin
   * Chlorethylbenzmethoxazone
   * 2-(2-Chloroethyl)-3-aza-4-chromanone
   * 2-(2-Chloroethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one
   * 2-(beta-Chloroethyl)-2,3-dihydro-4-oxo(benzo-1,3-oxazine)
   * 2-(2-Chloroethyl)-2,3-dihydro-4-oxo-1,3-benzoxazine
   * Chlorthenoxazin
   * Chlorthenoxazine
   * 4-Oxo-2-(beta-chloroethyl)-2,3-dihydrobenzo-1,3-oxazine
   * Reumagrip
   * Valmorin
   * Valtorin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,651,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 730 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,36,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11155 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 13,884,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1702 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 13,884,1963
 
                            *** END OF RECORD ***