*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DM4676000
CHEMICAL NAME           : 4-Benzoxazolecarboxylic acid,
                          5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-ox
                          o-2-(1H-
                          pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)meth
                          yl), (6S-(6-alpha(2S*,3S*),8-beta(R*),
                          9-beta,11-alpha))-
CAS REGISTRY NUMBER     : 52665-69-7
OTHER CAS REGISTRY NOS. : 51257-80-8
                          53095-21-9
LAST UPDATED            : 199503
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C29-H37-N3-O6
MOLECULAR WEIGHT        : 523.69
WISWESSER LINE NOTATION : T56 BN DOJ HM1 IVQ C1- FT6OXTJ E1 B-& BT6OXTJ C1 E1
                          FY1&V- BT5MJ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * A 23187
   * Antibiotic A23187
   * Calcimycin
   * Ionophore A23187
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   9,99,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson,
   M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
   Volume(issue)/page/year: 3,47,1978
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,123,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   469,281,1977
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >13 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,123,1988
 
                            *** END OF RECORD ***