*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DM0671500
CHEMICAL NAME : 1,2,4-Benzotriazine, 3-amino-, 1,4-dioxide
CAS REGISTRY NUMBER : 27314-97-2
BEILSTEIN REFERENCE NO. : 0179322
REFERENCE : 4-26-00-01120 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C7-H6-N4-O2
MOLECULAR WEIGHT : 178.17
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 3-Amino-1,2,4-benzotriazine-1,4-dioxide
* 1,2,4-Benzotriazin-3-amine, 1,4-dioxide
* SR 4233
* Tirapazamine
* WIN 59075
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 59390 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
66,100,1992
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >36 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Endocrine - other changes
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,154,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IOBPD3 International Journal of Radiation Oncology, Biology, Physics.
(Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
1975- Volume(issue)/page/year: 16,977,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 101 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Skin and Appendages - hair
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
BJCSB5 British Journal of Cancer, Supplement. (Macmillan Press Ltd.,
Houndmills, Basingstoke, Hants. RG21 2ZS, UK) No.1- 1973-
Volume(issue)/page/year: 20,84,1993
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 19 mg/kg/2W-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,154,1992
** MUTATION DATA **
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Liver
DOSE/DURATION : 500 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 11,1407,1990
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 500 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 11,1407,1990
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - rat Mammary gland
DOSE/DURATION : 500 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 11,1407,1990
*** END OF RECORD ***