*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DO7175000
CHEMICAL NAME           : Benzyl alcohol,
                          m-hydroxy-alpha-((methylamino)methyl)-, (-)-
CAS REGISTRY NUMBER     : 59-42-7
LAST UPDATED            : 199706
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C9-H13-N-O2
MOLECULAR WEIGHT        : 167.23
WISWESSER LINE NOTATION : QR CYQ1M1  -L
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-
   * l-alpha-Hydroxy-beta-methylamino-3-hydroxy-l-ethylbenzene
   * l-m-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
   * (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
   * l-1-(m-Hydroxyphenyl)-2-methylaminoethanol
   * l-(3-Hydroxyphenyl)-N-methylethanolamine
   * Isophrin
   * Mesaton
   * Mesatone
   * Metaoxedrin
   * Metaoxedrine
   * Metasympatol
   * Metasynephrine
   * m-Methylaminoethanolphenol
   * Mezaton
   * Neosynephrine
   * m-Oxedrine
   * (-)-m-Oxedrine
   * Phenylephrine
   * (-)-Phenylephrine
   * R(-)-Phenylephrine
   * Visadron
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 188 ug/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   36,187,1972
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 5500 ug/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   36,187,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 180,155,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 85,119,1945
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraduodenal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 180,155,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 160,22,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 875 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 28,46,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Cardiac - pulse rate increase, without fall in BP
   Skin and Appendages - hair
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   38,474,1976
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 20 ug/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 143,170,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 40 ug/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 143,170,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80598
       No. of Facilities: 97 (estimated)
       No. of Industries: 2
       No. of Occupations: 3
       No. of Employees: 183 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80598
       No. of Facilities: 147 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 6641 (estimated)
       No. of Female Employees: 5606 (estimated)

 
                            *** END OF RECORD ***