*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DR9823000
CHEMICAL NAME           : 13a-alpha-Berbine,
                          9,10-dimethoxy-2,3-(methylenedioxy)-
CAS REGISTRY NUMBER     : 5096-57-1
LAST UPDATED            : 199503
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H21-N-O4
MOLECULAR WEIGHT        : 339.42
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 6H-Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine,  
   5,8,13,13a-tetrahydro-9,10-dimethoxy-, (S)-
   * Canadine
   * (-)-Canadine
   * alpha-Canadine
   * 9,10-Dimethoxy-2,3-(methylenedioxy)berbine
   * Tetrahydroberberine
   * (-)-Tetrahydroberberine
   *   5,6,13,13a-Tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-8H-dibenzo(a,g
     )quinolizine
   * Xanthopuccine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 940 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,262,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 790 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,262,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,262,1989
 
                            *** END OF RECORD ***