*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DR9823500
CHEMICAL NAME           : 13a-alpha-Berbine-2,10-diol, 3,9-dimethoxy-
CAS REGISTRY NUMBER     : 16562-13-3
LAST UPDATED            : 198707
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H21-N-O4
MOLECULAR WEIGHT        : 327.41
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * 6H-Dibenzo(a,g)quinolizine-2,10-diol,  
   5,8,13,13a-tetrahydro-3,9-dimethoxy-, (S)-
   * l-2,10-Dihydroxy-3,9-dimethyloxytetrahydropseudoberberine
   * 3,9-Dimethoxy-13a-alpha-berbine-2,10-diol
   * Stepholidine
   * (-)-Stepholidine
   * l-Stepholidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 928 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   6,156,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 358 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   7,522,1986
 
                            *** END OF RECORD ***