*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DR9848050
CHEMICAL NAME           : 13a-alpha-Berbinium,
                          2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride
CAS REGISTRY NUMBER     : 104112-82-5
LAST UPDATED            : 198909
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C20-H24-N-O4.Cl
MOLECULAR WEIGHT        : 377.90
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * l-(-)-N-Methylcoreximine
   * Phellodendrine chloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 69500 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   58,138,1962
 
                            *** END OF RECORD ***