*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DR9867300
CHEMICAL NAME           : Berbinium,
                          7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylene
                          dioxy)-, sulfate (2:1)
CAS REGISTRY NUMBER     : 316-41-6
LAST UPDATED            : 198307
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C40-H36-N2-O8.O4-S
MOLECULAR WEIGHT        : 768.84
WISWESSER LINE NOTATION : T F5 D6 C666 GO IO OK HH&&T&&J RO1 SO1 2 &..S-O4
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium,  
   5,6-dihydro-9,10-dimethoxy-, sulfate (2:1)
   * Berberine sulfate
   * Berberine sulfate (2:1)
   * Berberin sulfate
   * Neutral berberine sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,770,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,770,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,770,1982
 
                            *** END OF RECORD ***