*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DS2800000
CHEMICAL NAME : Beryllium fluoride
CAS REGISTRY NUMBER : 7787-49-7
OTHER CAS REGISTRY NOS. : 12323-05-6
LAST UPDATED : 199712
DATA ITEMS CITED : 70
MOLECULAR FORMULA : Be-F2
MOLECULAR WEIGHT : 47.01
WISWESSER LINE NOTATION : BE F2
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Beryllium difluoride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-
Volume(issue)/page/year: 2173,23,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-
Volume(issue)/page/year: 2173,23,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-
Volume(issue)/page/year: 2173,23,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and
Development Reports. (Rochester, NY) Volume(issue)/page/year: UR-154,1951
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/m3/6H/30W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,493,1953
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 mg/m3/6H/15D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,493,1953
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1 mg/m3/6H/30W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Blood - other changes
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,493,1953
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 10 mg/m3/6H/30W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,493,1953
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 mg/m3/6H/30W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - other changes
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,493,1953
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10 mg/m3/6H/30W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,493,1953
** TUMORIGENIC DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 20 ug/m3/1H/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(7),34,1975
TYPE OF TEST : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 49 ug/m3/26W
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
2,203,1961
*** REVIEWS ***
ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-TWA 0.002 mg(Be)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 23,143,1980
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,41,1993
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 6,497,1973
TOXICOLOGY REVIEW
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 8,1,1953
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993
OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993
OEL-DENMARK:TWA 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-DENMARK:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993
OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FRANCE:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-FRANCE:TWA 2.5 mg(F)/m3 JAN 1993
OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993
OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993
OEL-POLAND:TWA 0.001 mg(Be)/m3 JAN 1993
OEL-POLAND:TWA 1 mg(F)/m3 JAN 1993
OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993
OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993
OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***