*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DU2100000
CHEMICAL NAME           : Biguanide, 1-phenethyl-
CAS REGISTRY NUMBER     : 114-86-3
BEILSTEIN REFERENCE NO. : 1977317
REFERENCE               : 4-12-00-02472 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C10-H15-N5
MOLECULAR WEIGHT        : 205.30
WISWESSER LINE NOTATION : MUYZMYUM&M2R
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
SYNONYMS/TRADE NAMES :
   * DBI
   * Fenformina
   * N'-beta-Fenetilformamidiniliminourea
   * NCI-C01741
   * PEDG
   * beta-Phenethylbiguanide
   * 1-Phenethylbiguanide
   * Phenethyldiguanide
   * N'-beta-Phenethylformamidinylliminourea
   * Phenformin
   * Phenformix
   * Phenylethylbiguanide
   * W 32
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 42,236,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 42,236,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   97,396,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MEXPAG Medicina Experimentalis.  (Basel, Switzerland)  V.1-11, 1959-64;
   V.18-19, 1968-69.  For publisher information, see JNMDBO.
   Volume(issue)/page/year: 8,237,1963
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - metabolic acidosis
REFERENCE :
   43ZRAD "Hemoperfusion: Kidney and Liver Support and Detoxification,
   Proceedings of the International Symposium, Haifa, 1979," Sideman, S., and
   T.M.S. Chang, eds., Multiple parts, New York, Hemisphere Pub. Corp., 1980-
   Volume(issue)/page/year: 1,337,1980

                          *** STATUS IN U.S. ***
 
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-7,77

 
                            *** END OF RECORD ***