*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DU3000000 CHEMICAL NAME : (delta(sup 2,2')-Biindoline)-5,5'-disulfonic acid, 3,3'-dioxo-, disodium salt CAS REGISTRY NUMBER : 860-22-0 LAST UPDATED : 199709 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C16-H8-N2-O8-S2.2Na MOLECULAR WEIGHT : 466.36 WISWESSER LINE NOTATION : T56 BMYVJ GSWO CU- CT56 BMYVJ GSWO &-NA- 2 COMPOUND DESCRIPTOR : Tumorigen Drug Mutagen SYNONYMS/TRADE NAMES : * Acid Blue W * Acid Leather Blue IC * A.F. Blue No. 2 * Airedale Blue IN * Amacid Brilliant Blue * Aniline Carmine powder * Atul Indigo Carmine * 1311 Blue * 12070 Blue * Bucacid indigotine B * Canacert Indigo Carmine * Carmine Blue (biological stain) * C.I. 73015 * C.I. 75781 * C.I. Acid Blue 74 * C.I. Food Blue 1 * C.I. Food Blue 1, disodium salt * Cilefa Blue R * C.I. Natural Blue 2 * Disodium indigo-5,5-disulfonate * Disodium salt of 1-indigotin-S,S'-disulphonic acid * Dolkwal Indigo Carmine * E 132 * Edicol Supra Blue X * FD and C Blue No. 2 * Food Blue 2 * Grape Blue A Geigy * HD Indigo Carmine * HD Indigo Carmine Supra * Hexacert Blue No. 2 * Hexacol Indigo Carmine Supra * Indigo Carmine * Indigo Carmine A * Indigo Carmine AC * Indigo Carmine (biological stain) * Indigo Carmine BP * Indigo Carmine Conc. FQ * Indigo Carmine disodium salt * Indigo Carmine powder * Indigo Carmine X * Indigo disulfonate (biological stain) * Indigo extract * Indigo-karmin * Indigotin I * 5,5'-Indigotindisulfonic acid * Indigotin-5,5'-disulfonic acid disodium salt * Indigotine * Indigotine B * Indigotine Blue LZ * Indigotine conc. powder * Indigotine disodium salt * Indigotine Extra Pure A * Indigotine I * Indigotine Lake * Indigotine N * Indocarmine F * Intense Blue * L-Blau 2 * Maple Indigo Carmine * Mitsui Indigo Carmine * Modr Kysela 74 * Modr Pigment 63 * Modr Potravinarska 1 * Murabba * Sachsischblau * San-ei Indigo Carmine * Schultz Nr. 1309 * Sodium indigotindisulfonate * Sodium 5,5'-indigotidisulfonate * Soluble indigo * Sumitomo Wool Blue SBC * Usacert Blue No. 2 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 47,39,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 93 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,83,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 47,39,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 405 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 47,39,1979 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9 gm/kg/2Y-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,29,1966 ** MUTATION DATA ** TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 5400 mg/kg/90D (Continuous) REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 54,25,1988 TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 60 mg/kg/30D (Continuous) REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 30,315,1986 TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 25 mg/kg REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 52,33,1990 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Fibroblast DOSE/DURATION : 12 gm/L REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 20 umol/L/5H (Continuous) REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84752 No. of Facilities: 314 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 1736 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84752 No. of Facilities: 393 (estimated) No. of Industries: 7 No. of Occupations: 28 No. of Employees: 9691 (estimated) No. of Female Employees: 3035 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***