*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DU3100000
CHEMICAL NAME           : (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde,
                          1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-
                          3,3'-dimethyl-
CAS REGISTRY NUMBER     : 303-45-7
BEILSTEIN REFERENCE NO. : 1917878
REFERENCE               : 4-08-00-03754 (Beilstein Handbook Reference)
LAST UPDATED            : 199803
DATA ITEMS CITED        : 18
MOLECULAR FORMULA       : C30-H30-O8
MOLECULAR WEIGHT        : 518.60
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 2,2'-Bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene)
   * 8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methyl-2,2'-bisnaphthalene
   * Gossypol
   * Tash 1
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2315 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAOCA7 Journal of the American Oil Chemists' Society.  (Champaign, IL)
   V.24-56, 1947-79.  Volume(issue)/page/year: 37,40,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JAOCA7 Journal of the American Oil Chemists' Society.  (Champaign, IL)
   V.24-56, 1947-79.  Volume(issue)/page/year: 40,571,1963
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 17 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   CMJODS Chinese Medical Journal (Beijing, English Edition).  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1975-    Adopted vol. no. 92 in 1979.  Volume(issue)/page/year: 4,417,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   CDESDK Contraceptive Delivery Systems.  (Kluwer Academic Pub. Group,
   Distribution Centre, POB 322, 3300 AH Dordrecht, Netherlands)  V.1- 1980- 
   Volume(issue)/page/year: 3,#278,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1050 mg/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   NFGZAD Nippon Funin Gakkai Zasshi.  Japanese Journal of Fertility and
   Sterility.  (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku,
   Toyko 162, Japan)  V.1-    1956-  Volume(issue)/page/year: 26,393,1981
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 4500 mg/kg
SEX/DURATION            : male 90 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   ARANDR Archives of Andrology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   13,199,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 525 mg/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 37,311,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 700 mg/kg
SEX/DURATION            : male 70 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 37,311,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,35,1984
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Lymphocyte
DOSE/DURATION           : 50 mg/L/48H
REFERENCE :
   ITCSAF In Vitro.  (Rockville, MD)  V.1-20, 1965-85.  For publisher
   information, see ICDBEO.  Volume(issue)/page/year: 19,53,1983
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human - man Lymphocyte
DOSE/DURATION           : 9 ug/plate
REFERENCE :
   CPHPA5 Jiepou Xuebao.  Journal of Anatomy.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)  V.1-9, 1953-66; V.10-
   1979-  Volume(issue)/page/year: 12,293,1981
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human - man Lymphocyte
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   CPHPA5 Jiepou Xuebao.  Journal of Anatomy.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)  V.1-9, 1953-66; V.10-
   1979-  Volume(issue)/page/year: 12,293,1981
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mg/L
REFERENCE :
   ITCSAF In Vitro.  (Rockville, MD)  V.1-20, 1965-85.  For publisher
   information, see ICDBEO.  Volume(issue)/page/year: 19,53,1983
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 50 mg/L
REFERENCE :
   ITCSAF In Vitro.  (Rockville, MD)  V.1-20, 1965-85.  For publisher
   information, see ICDBEO.  Volume(issue)/page/year: 19,53,1983
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mg/L/48H
REFERENCE :
   ITCSAF In Vitro.  (Rockville, MD)  V.1-20, 1965-85.  For publisher
   information, see ICDBEO.  Volume(issue)/page/year: 19,53,1983

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-rat; Sperm
   morphology-human
   
   EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-rabbit

 
                            *** END OF RECORD ***