*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DU3121500
CHEMICAL NAME           : (9,9'-Bi-4H-naphtho(2,3-b)pyran)-4,4'-dione,
                          2,2',3,3'-tetrahydro-5,5',6,6',8,8'-hexahydroxy-
                          2,2',3,3'-tetramethyl-
CAS REGISTRY NUMBER     : 75514-37-3
LAST UPDATED            : 199309
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C30-H26-O10
MOLECULAR WEIGHT        : 546.56
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Bis(naphthodihydropyran-4-one)
   * Chaetochromin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MAIKD3 Maikotokishin (Tokyo).  Mycotoxin.  (Maikotokishin Kenkyukai, c/o
   Tokyo Rika Daigaku Yakugakubu, 12 Funagawara-machi, Ichigaya, Shinjuku-ku,
   Tokyo 162, Japan)  No.1-    1975-  Volume(issue)/page/year: (12),28,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MAIKD3 Maikotokishin (Tokyo).  Mycotoxin.  (Maikotokishin Kenkyukai, c/o
   Tokyo Rika Daigaku Yakugakubu, 12 Funagawara-machi, Ichigaya, Shinjuku-ku,
   Tokyo 162, Japan)  No.1-    1975-  Volume(issue)/page/year: (12),28,1980
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >80 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MAIKD3 Maikotokishin (Tokyo).  Mycotoxin.  (Maikotokishin Kenkyukai, c/o
   Tokyo Rika Daigaku Yakugakubu, 12 Funagawara-machi, Ichigaya, Shinjuku-ku,
   Tokyo 162, Japan)  No.1-    1975-  Volume(issue)/page/year: (12),28,1980
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 64800 ug/kg
SEX/DURATION            : female 1-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 39,299,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 21600 ug/kg
SEX/DURATION            : female 1-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 39,299,1987
 
                            *** END OF RECORD ***