*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DV4550000
CHEMICAL NAME : 2,5-Biphenyldiol
CAS REGISTRY NUMBER : 1079-21-6
BEILSTEIN REFERENCE NO. : 1949429
REFERENCE : 3-06-00-05371 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C12-H10-O2
MOLECULAR WEIGHT : 186.22
WISWESSER LINE NOTATION : QR DQ BR
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* (1,1'-Biphenyl)-2,5-diol
* 2,5-Dihydroxybiphenyl
* Hydroquinone, phenyl-
* Phenylhydroquinone
* o-Phenylhydroquinone
* 2-Phenylhydroquinone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1010 mg/m3/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534853
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 6,222,1954
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 22,221,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 mg/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534850
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 10 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
76,163,1990
TYPE OF TEST : DNA adduct
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 13,1937,1992
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,309,1993
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,1,1991
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,1,1991
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***