*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DV5357000
CHEMICAL NAME           : 1,1'-Biphenyl, 2,2',3,3',4,4'-hexachloro-
CAS REGISTRY NUMBER     : 38380-07-3
BEILSTEIN REFERENCE NO. : 2508232
LAST UPDATED            : 199801
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C12-H4-Cl6
MOLECULAR WEIGHT        : 360.86
WISWESSER LINE NOTATION : GR BG CG DR BG CG DG
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2,2',3,3',4,4'-Hexachlorobiphenyl
   * 2,3,4,2',3',4'-Hexachlorobiphenyl
   * PCB 128
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 383 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - other changes
   Endocrine - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 51,265,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 1470 mg/kg/21D-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - cytochrome oxidases (including oxidative phosphorylation)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   36,81,1976
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 320 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 21,54A,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1280 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 21,54A,1980

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***