*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : DV8660000 CHEMICAL NAME : 1,1'-Biphenyl, 2,2',5,5'-tetrachloro- CAS REGISTRY NUMBER : 35693-99-3 BEILSTEIN REFERENCE NO. : 2053828 REFERENCE : 4-05-00-01818 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C12-H6-Cl4 MOLECULAR WEIGHT : 291.98 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * PCB 52 * 2,2',5,5'-TCB * 2,2',5,5'-Tetrachlorobiphenyl * 2,5,2',5'-Tetrachlorobiphenyl *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg/3D-I TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg/4D-I TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 100,315,1989 ** MUTATION DATA ** TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Fibroblast DOSE/DURATION : 20 mg/L REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 24,313,1979 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***