*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DW2973000
CHEMICAL NAME           : N,4'-Bi(pyrrole-2-carboxamide),
                          N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amin
                          o)-1,1'- dimethyl-
CAS REGISTRY NUMBER     : 1438-30-8
OTHER CAS REGISTRY NOS. : 554-32-5
BEILSTEIN REFERENCE NO. : 0376913
REFERENCE               : 4-22-00-06712 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C18-H26-N10-O3
MOLECULAR WEIGHT        : 430.54
WISWESSER LINE NOTATION : T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * 2814-A
   * Antibiotic 1142
   * Antibiotic T-1384
   * CH-777-A
   * Congocidin
   * Congocidine
   * F 6
   * IA 887
   * K-117
   * Netropsin
   * Sinanomycin
   * T 1384
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1180,1978
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 9,102,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1180,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1180,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 40 mg/L/3H
REFERENCE :
   CRSUBM Cancer Research Supplement.  (Baltimore, MD)  No.1-4, 1953-56.
   Volume(issue)/page/year: 3,69,1955
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 mg/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,1144,1980
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MLBRBU Molecular Biology Reports.  (Dr. W. Junk Pub., POB 163, 3300 AD
   Dordrect, Netherlands) V.1-    1973-  Volume(issue)/page/year: 2,135,1975
 
                            *** END OF RECORD ***