*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EC5990500
CHEMICAL NAME           : Bleomycinamide, N'-(3-((4-aminobutyl)amino)propyl)-
CAS REGISTRY NUMBER     : 11116-32-8
LAST UPDATED            : 199506
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C57-H89-N19-O21-S2
MOLECULAR WEIGHT        : 1440.77
WISWESSER LINE NOTATION : T6OTJ BQ CQ DOVZ EQ FO- CT6OTJ DQ EQ FQ BOY- DT5M
                          CNJ&YVMY1&YQY1&VNYYQ1&VM2- BT5N CSJ E-
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * N1-(3-((4-Aminobutyl)amino)propyl)bleomycinamide
   * Bleomycetin
   * Bleomycin A5
   * Pingyangmycin
   * Zhengguangmycin A5
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human
DOSE/DURATION           : 192 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 28,632,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 199,199,1988
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   34,878,1974
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 400 ug/L
REFERENCE :
   HKXUDL Huanjing Kexue Xuebao.  Environmental Sciences Journal.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1981-  Volume(issue)/page/year: 3,78,1983
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 400 ug/L
REFERENCE :
   HKXUDL Huanjing Kexue Xuebao.  Environmental Sciences Journal.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 
     1981-  Volume(issue)/page/year: 3,78,1983
 
                            *** END OF RECORD ***