*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EC5991200
CHEMICAL NAME           : Bleomycinamide, N(sup
                          1)-(4-((aminoiminomethyl)amino)butyl)-
CAS REGISTRY NUMBER     : 9060-10-0
BEILSTEIN REFERENCE NO. : 0973538
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C55-H84-N20-O21-S2
MOLECULAR WEIGHT        : 1425.71
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Bleomycin B(sub 2)
   * Bleomycin B2
   * Dehydrophleomycin D1
   * Phleomycin D2
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosis (interstitial)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   56,326,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 117,9,1983
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 umol/L
REFERENCE :
   BICHAW Biochemistry.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1962-
   Volume(issue)/page/year: 21,4310,1982
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 100 mg/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 28,537,1975
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10700 pmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,4173,1980
 
                            *** END OF RECORD ***