*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EC5991325
CHEMICAL NAME           : Bleomycinamide, N(sup
                          1)-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-
CAS REGISTRY NUMBER     : 37293-17-7
OTHER CAS REGISTRY NOS. : 11032-73-8
LAST UPDATED            : 199607
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C60-H96-N20-O21-S2
MOLECULAR WEIGHT        : 1497.88
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N(sup 1)-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)bleomycinamide
   * Bleomycin A6
   * Boanmycin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKZAEY Zhongguo Kangshengsu Zazhi.  Chinese Journal of Antibiotics.
   (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop.
   Rep. China)  V.13-    1988-  Volume(issue)/page/year: 15,453,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80330 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKZAEY Zhongguo Kangshengsu Zazhi.  Chinese Journal of Antibiotics.
   (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop.
   Rep. China)  V.13-    1988-  Volume(issue)/page/year: 15,453,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 97780 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKZAEY Zhongguo Kangshengsu Zazhi.  Chinese Journal of Antibiotics.
   (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop.
   Rep. China)  V.13-    1988-  Volume(issue)/page/year: 15,453,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70530 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKZAEY Zhongguo Kangshengsu Zazhi.  Chinese Journal of Antibiotics.
   (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop.
   Rep. China)  V.13-    1988-  Volume(issue)/page/year: 15,453,1990
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 24500 ug/kg/7W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   ZKZAEY Zhongguo Kangshengsu Zazhi.  Chinese Journal of Antibiotics.
   (Zhongguo Kangshengsu Zazhi Bianjibu, 9 Shanbanqiaolu, Chenqdu, 610051 Peop.
   Rep. China)  V.13-    1988-  Volume(issue)/page/year: 15,453,1990
 
                            *** END OF RECORD ***