*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ED4588000
CHEMICAL NAME           : Boric acid, disodium salt
CAS REGISTRY NUMBER     : 1330-43-4
OTHER CAS REGISTRY NOS. : 1332-28-1
LAST UPDATED            : 199712
DATA ITEMS CITED        : 18
MOLECULAR FORMULA       : B4-O7.2Na
MOLECULAR WEIGHT        : 201.22
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Anhydrous borax
   * Borates, tetra, sodium salt, anhydrous
   * Borax glass
   * Disodium tetraborate
   * FR 28
   * Fused borax
   * Rasorite 65
   * Sodium biborate
   * Sodium boron oxide
   * Sodium tetraborate
   * Sodium tetraborate (Na2B4O7)
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 26 gm/kg/14W-C
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
   Biochemical - Metabolism (Intermediary) - xanthine, purine or nucleotides
   including urate
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 10,219,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16750 ug/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 13,59,1976

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 1 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 1 mg/m3 JAN 1993
   
   OEL-BELGIUM:TWA 1 mg/m3 JAN 1993
   
   OEL-DENMARK:TWA 1 mg/m3 JAN 1993
   
   OEL-FRANCE:TWA 1 mg/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 mg/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 1 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 1 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - B0085
       No. of Facilities: 1170 (estimated)
       No. of Industries: 34
       No. of Occupations: 27
       No. of Employees: 5513 (estimated)
   
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M3899
       No. of Facilities: 5 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 101 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M3899
       No. of Facilities: 6225 (estimated)
       No. of Industries: 87
       No. of Occupations: 57
       No. of Employees: 78116 (estimated)
       No. of Female Employees: 15080 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***