*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ED9500000
CHEMICAL NAME           : Bouvardin
CAS REGISTRY NUMBER     : 64755-14-2
BEILSTEIN REFERENCE NO. : 6045458
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C40-H48-N6-O10
MOLECULAR WEIGHT        : 772.94
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * NSC 259968
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12430 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   IJPPAZ Indian Journal of Physiology and Pharmacology.  (All India Institute
   of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029,
   India)  V.1-    1957-  Volume(issue)/page/year: 23,414,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 3160 nmol/L
REFERENCE :
   TUMOAB Tumori.  (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
   Italy)  V.1-    1911-  Volume(issue)/page/year: 71,261,1985
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 umol/L
REFERENCE :
   TUMOAB Tumori.  (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
   Italy)  V.1-    1911-  Volume(issue)/page/year: 71,261,1985
 
                            *** END OF RECORD ***