*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EI2962500
CHEMICAL NAME : 5-beta-Bufa-20,22-dienolide, 3-beta,14-dihydroxy-
CAS REGISTRY NUMBER : 465-21-4
BEILSTEIN REFERENCE NO. : 5141601
LAST UPDATED : 199709
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C24-H34-O4
MOLECULAR WEIGHT : 386.58
WISWESSER LINE NOTATION : L E5 B666TJ A1 E1 IQ OQ F- ET6OVJ
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-
* Bufalin
* 3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 740 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 24,1714,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 140 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year:
-,189,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 137 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung,
Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926-
Volume(issue)/page/year: 24,222,1949
*** END OF RECORD ***