*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : EI2968500 CHEMICAL NAME : Bufa-20,22-dienolide, 5,14-dihydroxy-3-((3-methyl-1-oxo-2-butenyl)oxy)-19-o xo-, (3-beta,5-beta)- CAS REGISTRY NUMBER : 67696-82-6 LAST UPDATED : 199406 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C29-H38-O7 MOLECULAR WEIGHT : 498.67 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Acrihelina * Acrihellin * D 12316 * (3-beta,5-beta)-5,14-Dihydroxy-3-((3-methyl-1-oxo-2-butenyl)oxy)-19-oxob ufa-20,22-dienolide * 3-beta,5,14-Trihydroxy-19-oxo-5-beta-bufa-20,22-dienolide 3-(3-methylcrotonate) *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1740 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 457 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 545 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5680 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 835 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 400 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 159 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : >520 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 130 ug/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - nausea or vomiting REFERENCE : NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,219,1985 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 160 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,769,1984 *** END OF RECORD ***