*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EI2968500
CHEMICAL NAME           : Bufa-20,22-dienolide,
                          5,14-dihydroxy-3-((3-methyl-1-oxo-2-butenyl)oxy)-19-o
                          xo-, (3-beta,5-beta)-
CAS REGISTRY NUMBER     : 67696-82-6
LAST UPDATED            : 199406
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C29-H38-O7
MOLECULAR WEIGHT        : 498.67
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acrihelina
   * Acrihellin
   * D 12316
   *   (3-beta,5-beta)-5,14-Dihydroxy-3-((3-methyl-1-oxo-2-butenyl)oxy)-19-oxob
     ufa-20,22-dienolide
   * 3-beta,5,14-Trihydroxy-19-oxo-5-beta-bufa-20,22-dienolide  
   3-(3-methylcrotonate)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1740 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 457 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 545 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5680 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 835 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 159 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >520 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 130 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,219,1985
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 160 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,769,1984
 
                            *** END OF RECORD ***