*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : EC1210000 CHEMICAL NAME : m,m'-Bitolyl-4,4'-diol, alpha,alpha'-bis(diethylamino)-5,5'-diallyl-, dihydrochloride CAS REGISTRY NUMBER : 3624-96-2 LAST UPDATED : 199606 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C28-H40-N2-O2.2Cl-H MOLECULAR WEIGHT : 509.62 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Bialamicol hydrochloride * Biallylamicol dihydrochloride * Biallylamicol hydrochloride * (1,1'-Biphenyl)-4,4'-diol, 3,3'-bis((diethylamino)methyl)-5,5'-di-2-propenyl-, 2HCl * alpha,alpha'-Bis(diethylamino)-5,5'-diallyl-m,m'-bitolyl-4,4'-diol dihydrochloride * Camoform hydrochloride * PAA-701 dihydrochloride * SN 6771 dihydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 243 mg/kg/9D TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase REFERENCE : 85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2 vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year: 1,304,1946 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : 85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2 vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year: 1,304,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1649 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,113,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3950 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,113,1957 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >470 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : 85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2 vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year: 1,304,1946 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4950 mg/kg/2W-C TOXIC EFFECTS : Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,113,1957 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1220 mg/kg/24W-C TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,113,1957 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3825 mg/kg/9D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : 85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2 vols., Ann Arbor, MI, J.W. Edwards, 1946 Volume(issue)/page/year: 1,304,1946 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 4995 mg/kg/26W-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,113,1957 *** END OF RECORD ***