*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EJ7000000
CHEMICAL NAME           : 1,4-Butanediamine, N-(3-aminopropyl)-
CAS REGISTRY NUMBER     : 124-20-9
BEILSTEIN REFERENCE NO. : 1698591
REFERENCE               : 4-04-00-01300 (Beilstein Handbook Reference)
LAST UPDATED            : 199706
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C7-H19-N3
MOLECULAR WEIGHT        : 145.29
WISWESSER LINE NOTATION : Z4M3Z
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1,4-Diaminobutane, N-(3-aminopropyl)-
   * Spermidine
   * 1,5,10-Triazadecane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD30 - Lethal Dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 14,228,1984
 
TYPE OF TEST            : LD30 - Lethal Dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 14,228,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 198,36,1972
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 9504 gm/kg/14D-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Liver - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 44,518,1996
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MGGEAE Molecular and General Genetics.  (Springer-Verlag, Heidelberger Pl.
   3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.99-    1967-
   Volume(issue)/page/year: 178,21,1980
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   146,697,1975
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,175,1986
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lung
DOSE/DURATION           : 200 mmol/L
REFERENCE :
   IJRBA3 International Journal of Radiation Biology and Related Studies in
   Physics, Chemistry and Medicine.  (Taylor & Francis Inc., 242 Cherry St.,
   Philadelphia, PA 19106)  V.1-    1959-  Volume(issue)/page/year: 9,185,1965

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***