*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : EJ8575000 CHEMICAL NAME : Butane, L-1,2:3,4-diepoxy- CAS REGISTRY NUMBER : 30031-64-2 LAST UPDATED : 199510 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C4-H6-O2 MOLECULAR WEIGHT : 86.10 WISWESSER LINE NOTATION : T3OTJ B- BT3OTJ -L COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * (S-(R*,R*))-2,2'-Bioxirane * L-Butadiene diepoxide * L-Diepoxybutane * L-1,2:3,4-Diepoxybutane * (2S,3S)-Diepoxybutane * (2S,3S)-1,2:3,4-Diepoxybutane * NSC-32606 *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 110 mg/kg/4W TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 36,915,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 192 mg/kg/4W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors REFERENCE : NCISA* Progress Report for Contract No. PH-43-63-1132, Submitted to the National Cancer Institute by Scientific Associates, Inc. (6200 S. Lindberg Blvd., St. Louis, MO 63123) Volume(issue)/page/year: PH-43-62-483 ** MUTATION DATA ** TYPE OF TEST : DNA damage TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 5 mmol/L REFERENCE : BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 228,400,1971 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Schizosaccharomyces pombe DOSE/DURATION : 31 mmol/L REFERENCE : ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued. Volume(issue)/page/year: -,193,1962 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 11,115,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 11,115,1976 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion *** END OF RECORD ***