*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EJ8575000
CHEMICAL NAME           : Butane, L-1,2:3,4-diepoxy-
CAS REGISTRY NUMBER     : 30031-64-2
LAST UPDATED            : 199510
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C4-H6-O2
MOLECULAR WEIGHT        : 86.10
WISWESSER LINE NOTATION : T3OTJ B- BT3OTJ  -L
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * (S-(R*,R*))-2,2'-Bioxirane
   * L-Butadiene diepoxide
   * L-Diepoxybutane
   * L-1,2:3,4-Diepoxybutane
   * (2S,3S)-Diepoxybutane
   * (2S,3S)-1,2:3,4-Diepoxybutane
   * NSC-32606
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg/4W
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   36,915,1966
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 192 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Endocrine - tumors
REFERENCE :
   NCISA* Progress Report for Contract No. PH-43-63-1132, Submitted to the
   National Cancer Institute by Scientific Associates, Inc.  (6200 S. Lindberg
   Blvd., St. Louis, MO 63123)  Volume(issue)/page/year: PH-43-62-483
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   228,400,1971
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 31 mmol/L
REFERENCE :
   ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin,
   Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.)  1950-68.  Discontinued.
   Volume(issue)/page/year: -,193,1962

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 11,115,1976

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 11,115,1976

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion

 
                            *** END OF RECORD ***