*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EJ9857500
CHEMICAL NAME           : Butanedioic acid, compd. with
                          8-chloro-5-methyl-11-(4-methyl-1-piperazinyl)-5H-pyrr
                          olo(1,2-b) (1,2,5)benzotriazepine (1:1)
CAS REGISTRY NUMBER     : 102636-45-3
LAST UPDATED            : 199506
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H20-Cl-N5.C4-H6-O4
MOLECULAR WEIGHT        : 447.97
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Sandoz 200-125
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 43680 mg/kg/26W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Blood - changes in leukocyte (WBC) count
   Blood - changes in platelet count
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 13,335,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8750 mg/kg/4W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - changes in lung weight
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 13,335,1985
 
                            *** END OF RECORD ***