*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EJ9974000
CHEMICAL NAME           : Butanedioic acid,
                          mono((6-(3-(3-carboxy-1-oxopropoxy)-3,4-dihydro-5,7-d
                          ihydroxy-4-oxo-2H-1-
                          benzopyran-2-yl)-2,3-dihydro-3-(4-hydroxy-3-methoxyph
                          enyl)-1,4-benzodioxin -2-yl)methyl) ester, disodium
                          salt, (2R-(2-alpha,3-beta,6(2R*,3R*)))-
CAS REGISTRY NUMBER     : 55254-34-7
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C33-H28-O16.2Na
MOLECULAR WEIGHT        : 726.59
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * SIHS sodium
   * Silibinin-2',3-dihydrogensuccinate sodium salt
   * Silybin dihemisuccinate disodium
   * Silybin disodium hemisuccinate
   * Silybin hemisuccinate sodium salt
   * Silybin sodium dihemisuccinate
   * Silybin sodium hemisuccinate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1076 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella
   Postale 227, 27100 Pavia, Italy)  V.44-   1989-  Volume(issue)/page/year:
   49,75,1994
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 27 mg/kg
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   35,538,1986
 
                            *** END OF RECORD ***