*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EB2984000
CHEMICAL NAME           : Bismuthine, tris((carboxymethyl)thio)-, trisodium
                          salt
CAS REGISTRY NUMBER     : 150-49-2
LAST UPDATED            : 199609
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C6-H6-Bi-O6-S3.3Na
MOLECULAR WEIGHT        : 548.25
WISWESSER LINE NOTATION : VHO1S-BI-S1OVHS1OVH &-NA- 3
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Bismuth sodium thioglycollate
   * Mercaptoacetic acid, sodium-bismuth salt
   * Sodium bismuth thioglycolate
   * Sodium bismuth thioglycollate
   * Thio-Bismol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 47222 mg/kg/22W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   198,187,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Behavioral - coma
   Kidney, Ureter, Bladder - urine volume decreased
   Skin and Appendages - other glands
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   28,493,1946
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 650 ug/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   AMDCA5 AMA Journal of Diseases of Children.  (Chicago, IL)  V.91-99,
   1956-60.  For publisher information, see AJDCAI.  Volume(issue)/page/year:
   97,384,1959
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   31,580,1947
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
   JCHOAM Journal of Chemotherapy.  (Philadelphia, PA)  V.4-11(1), 1927-34.
   Volume(issue)/page/year: 10,77,1934

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AJMEAZ American Journal of Medicine.  (Technical Pub., 875 Third Ave., New
   York, NY 10022) V.1-    1946-  Volume(issue)/page/year: 38,409,1965

 
                            *** END OF RECORD ***