*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EJ9980000
CHEMICAL NAME           : Butanedioic acid,
                          mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(
                          4,3-j)-1,2- benzodioxepin-10-yl)ester, sodium salt,
                          (3R-(3-alpha,5a-beta,6-beta,8a-beta,9-alpha,10-
                          alpha,12-beta,12aR*))-
CAS REGISTRY NUMBER     : 82864-68-4
LAST UPDATED            : 199503
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H27-O8.Na
MOLECULAR WEIGHT        : 406.45
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * SM 804
   * Sodium artesunate
   * Sodium dihydroarteannuin hydrogen succinate monoester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 438 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYTPDT Zhongyao Tongbao.  Bulletin of Chinese Materia Medica.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
   V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3
   Volume(issue)/page/year: 13,234,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,99,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 475 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China
   Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese
   Medicine)  V.1-    1981-  Volume(issue)/page/year: 2,99,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 630 mg/kg/14D-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 1,135,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5400 ug/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   CYTPDT Zhongyao Tongbao.  Bulletin of Chinese Materia Medica.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
   V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3
   Volume(issue)/page/year: 13,234,1988
 
                            *** END OF RECORD ***