*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EK1225000
CHEMICAL NAME           : 1,3-Butanediol, cyclic sulfite
CAS REGISTRY NUMBER     : 4426-51-1
BEILSTEIN REFERENCE NO. : 1237514
REFERENCE               : 4-01-00-02510 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C4-H8-O3-S
MOLECULAR WEIGHT        : 136.18
WISWESSER LINE NOTATION : T6OSOTJ BO D1
SYNONYMS/TRADE NAMES :
   * 1,3,2-Dioxathiane, 4-methyl-, 2-oxide
   * 4-Methyl-trimethylene sulfite
   * NSC-60195
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 780 mg/kg/13D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Kidney, Ureter, Bladder - hematuria
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 560 mg/kg/14D-I
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   NCISS* Progress Report Submitted to the National Cancer Institute by South
   Shore Analytical and Research Laboratory.  Volume(issue)/page/year:
   -,57,1964
 
                            *** END OF RECORD ***