*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EK7907000
CHEMICAL NAME : Butanoic acid, 2-methyl-,
1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-
4-hydroxy- 6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl
ester, (1S-(1-alpha-(R*),3-alpha,7-beta,
8-beta-(2S*,4S*),8a-beta))-
CAS REGISTRY NUMBER : 75330-75-5
OTHER CAS REGISTRY NOS. : 71949-96-7
74133-25-8
BEILSTEIN REFERENCE NO. : 3631989
LAST UPDATED : 199801
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C24-H36-O5
MOLECULAR WEIGHT : 404.60
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Lovastatin
* 6-alpha-Methylcompactin
* Mevacor
* Mevinacor
* Mevinolin
* MK 803
* Monacolin K
* MSD 803
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 8750 ug/kg/14D-I
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960-
Volume(issue)/page/year: 50,730,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 240 mg/kg/60W-I
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696,
Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 26,190,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 17 mg/kg/3W-I
TOXIC EFFECTS :
Behavioral - wakefulness
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 343,973,1994
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 285 mg/kg/30W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - liver function tests impaired
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,
Israel) V.1- 1965- Volume(issue)/page/year: 28,101,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 32,852,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/kg/5D-I
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 32,852,1979
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 9600 mg/kg
SEX/DURATION : female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 28,449,1983
*** END OF RECORD ***