*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EK7938000
CHEMICAL NAME           : Butanoic acid,
                          3-((6-(4-morpholinyl)-3-pyridazinyl)hydrazono)-,
                          1,1-dimethyl ethyl ester
CAS REGISTRY NUMBER     : 69579-13-1
BEILSTEIN REFERENCE NO. : 0833936
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C16-H25-N5-O3
MOLECULAR WEIGHT        : 335.46
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Butyric acid, 3-(2-(6-morpholino-3-pyridazinyl)hydrazinylidene)-,  
   tert-butyl ester
   * GYKI 11679
   *   1-(6-Morpholino-3-pyridazinyl)-2-(1-(tert-butoxycarbonyl)-2-propylidene)
     hydrazine
   *   1-(6-Morpholino-3-pyridazinyl)-2-(1-(tert-butoxycarbonyl)-2-propyliden)h
     ydrazin
   * 3-(2-(6-Morpholino-3-pyridazinyl)hydrazinylidene)butyric acid tert-butyl  
   ester
   * 3-((6-(4-Morpholinyl)-3-pyridazinyl)hydrazono)butanoic acid 1,1-dimethyl  
   ethyl ester
   * RGH-5526
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 970 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   10,32,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 670 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   10,32,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 19,111,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   10,32,1985
 
                            *** END OF RECORD ***