*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EL2350000
CHEMICAL NAME           : 2-Butanol,
                          1-(dimethylamino)-2-((dimethylamino)methyl)-,
                          benzoate, (ester)
CAS REGISTRY NUMBER     : 963-07-5
BEILSTEIN REFERENCE NO. : 3326602
REFERENCE               : 2-09-00-00154 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C16-H26-N2-O2
MOLECULAR WEIGHT        : 278.44
WISWESSER LINE NOTATION : 1N1&1X2&OVR&1N1&1
SYNONYMS/TRADE NAMES :
   * Alypin
   * Alypine
   * Amydricaine
   * Amydrikain
   * Benzopropyl
   * 1,1-Bis-(dimethylaminoethyl)propylester kyseliny benzoove
   * 1-(Dimethylamino)-2-((dimethylamino)methyl)-2-butanol benzoate
   * Dimethylaminostovaine
   * 2-Ethyl-1,3-bis(dimethylamino)-2-propanol benzoate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraspinal
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 45,291,1932

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   12,190,1932

 
                            *** END OF RECORD ***