*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EL2975000
CHEMICAL NAME : 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-,
propionate (ester)
CAS REGISTRY NUMBER : 77-50-9
LAST UPDATED : 199610
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C22-H29-N-O2
MOLECULAR WEIGHT : 339.52
WISWESSER LINE NOTATION : 2VOXR&1R&Y1&1N1&1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-,
propanoate (ester)
* 1,2-Difenyl-4-dimethylamino-3-methyl-2-butylester kyseliny propionove
* alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate
* alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-4-propionyloxybutane
* alpha-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanolpropionate
* 4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate
* 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane
* alpha-N,N-Dimethyl-3,4-diphenyl-2-methyl-3-propionoxy-1-butylamine
* 1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane
* Letusin
* Propionic acid,
alpha-(2-dimethylamino-1-methylethyl)-alpha-phenylphenethyl ester
* Propoxyphene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiectasis
Liver - fatty liver degeneration
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 10,327,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 990 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1,1,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
53,77,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 34700 ug/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see
JPMSAE. Volume(issue)/page/year: 44,497,1955
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 350 mg/kg
SEX/DURATION : female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 17,39A,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 90 mg/kg
SEX/DURATION : male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1975- Volume(issue)/page/year:
36,49,1980
*** REVIEWS ***
TOXICOLOGY REVIEW
KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972-
Volume(issue)/page/year: 10,82,1976
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
Volume(issue)/page/year: 19,361,1973
*** END OF RECORD ***