*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : EL2975000
CHEMICAL NAME           : 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-,
                          propionate (ester)
CAS REGISTRY NUMBER     : 77-50-9
LAST UPDATED            : 199610
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C22-H29-N-O2
MOLECULAR WEIGHT        : 339.52
WISWESSER LINE NOTATION : 2VOXR&1R&Y1&1N1&1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-,  
   propanoate (ester)
   * 1,2-Difenyl-4-dimethylamino-3-methyl-2-butylester kyseliny propionove
   * alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-2-butanol propionate
   * alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-4-propionyloxybutane
   * alpha-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanolpropionate
   * 4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate
   * 4-Dimethylamino-3-methyl-1,2-diphenyl-2-propoxybutane
   * alpha-N,N-Dimethyl-3,4-diphenyl-2-methyl-3-propionoxy-1-butylamine
   * 1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane
   * Letusin
   * Propionic acid,  
   alpha-(2-dimethylamino-1-methylethyl)-alpha-phenylphenethyl ester
   * Propoxyphene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - bronchiectasis
   Liver - fatty liver degeneration
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 10,327,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 990 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 1,1,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   53,77,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34700 ug/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 44,497,1955
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 350 mg/kg
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 17,39A,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 90 mg/kg
SEX/DURATION            : male 3 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   PCBRD2 Progress in Clinical and Biological Research.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1975- Volume(issue)/page/year:
   36,49,1980

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   KDYIA5 Kidney International.  (Springer-Verlag New York, Inc., Service
   Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094)  V.1-    1972-
   Volume(issue)/page/year: 10,82,1976

   TOXICOLOGY REVIEW
   CLCHAU Clinical Chemistry (Winston-Salem, NC).  (American Assoc. for
   Clinical Chemistry, 1725 K St., NW, Washington, DC 20006)  V.1-    1955-
   Volume(issue)/page/year: 19,361,1973

 
                            *** END OF RECORD ***